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Nrf2 also regulates the expression of genes that control inflammatory and immune system responses (Kasprzak et al., 2020)

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Interestingly, in renal clear cell carcinoma, IDO expressed by neovascularization endothelial cells is an inhibitory factor in tumor growth because it limits the flow of tryptophan from the blood to the tumor or produces tumor toxic substances (Riesenberg et al., 2007)
