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mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation

On the contrary, glutamine supplementation reduced the activation of the PI3K/Akt pathway, which reversed claudin-1 expression in the cells, suggesting that glutamine supplementation regulates phosphorylation states of tight junction proteins

Although immunohistochemical analyses have found B cell-rich tertiary lymphoid structures in most brains from patients with MS, but not in the two PD patients investigated (92), there is ample evidence for the involvement of B cells, antibodies, and humoral immune effector mechanisms in PD (9395)
