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[DOI] [PMC free article] [PubMed] [Google Scholar] 106.Mazahery H., Stonehouse W., Delshad M., Kruger M.C., Conlon C.A., Beck K.L
reported that the small ARF-like GTPase Arl8b regulates this mechanism and can be inhibited by the Rab7 GTPase competitive inhibitor CID1067700
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Then, the rate-limiting enzyme in arginine synthesis, argininosuccinate synthetase 1 (ASS1), catalyzes the conversion of citrulline and aspartate into argininosuccinate, which is then cleaved into arginine and fumarate by argininosuccinate lyase (ASL) (Figure 1)

Abbreviations, HMs, heavy metals
