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Furthermore, another study in zebrafish also found that exposure to concentrated copper (111000 g/L) led to faster heart rates at 28 h postfertilization (hpf) zebrafish embryos, suggesting a stress response in fish embryos [35]

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Given the importance of glial pathology in the pathogenesis of bipolar disorder and the key role played by GDNF in stabilizing microglia activation and the propagation of peripheral inflammatory signaling in the CNS, we hope that future, methodologically rigorous studies may elucidate its disease state-dependent changes