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L-carnitine reserves can be used up completely if there is a larger amount of excess acetyl-CoA that needs to be buffered out of the mitochondria [15]

Indeed, the PDH complex, which decarboxylates glycolytically derived pyruvate to acetyl coenzyme A and links cytoplasmic glycolysis to the mitochondrial tricarboxylic acid (TCA) cycle, is modulated by reversible phosphorylation by PDH kinase (PDK)

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