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And then, I got to do other interesting exploratory work

Oral dosing keeps plasma ascorbate below roughly 220 micromoles per liter (mol/L), whereas controlled IV infusion can safely **generate** pharmacologic concentrations of 2530 millimoles per liter (mmol/L)a finding documented by Mark Levines National Institutes of Health group in Vitamin C pharmacokinetics: implications for oral and intravenous use (Padayatty and colleagues, Annals of Internal Medicine, 2004)

48 , 49 Vitamin B 12 contributes to improving the immune response via an increase in CD8 + T cells and natural killer T cells

Eur J Clin Invest 1990;20:199207