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Description
Insulin opposes GH-mediated lipolysis
The presence of melanin and tumor lysate enables local heat release upon near-infrared (NIR) light exposure, which in turn triggers the release of inflammatory cytokines, attracting immune cells and producing immunogenic cytokines to activate the immune system
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The mechanistic basis for this synergy involves complementary intracellular signaling pathways: GHRH primarily activates the cAMP-PKA pathway to stimulate GH gene transcription and GH vesicle exocytosis, while GHS-R1a agonists primarily activate the IP3-calcium pathway to trigger rapid GH granule fusion and secretion
