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Its role in long-term weight management is debated
After taking a closer look at the calculated ECD spectra of the other conformers (Figure S10), many of them also reach a reasonable agreement with the experimental spectrum, but their band maxima and/or relative intensities of the bands do not provide such a good agreement as the two conformers proposed by the shapefitting algorithm

Vitamin B12 deficiency can cause complications if it is not treated

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