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Patients were reviewed by heart failure specialist nurses and doctors at regular intervals, usually at 4 and 12 months, and then annually, unless an appointment was requested sooner by the patient, physician or specialist nurse

Raygoza Garay, J
Senolytics , drugs that clear the worn-out senescent cells that accumulate with age, are the more serious candidate

See Chapter 20, Paragraph 20.4.5
