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Crucial stages of ferroptosis include the accumulation of iron, lipid peroxidation, and GPX4 inactivation, all of which contribute to intestinal oxidative damage due to iron overload, leading to lipid peroxidation accumulation and potentially triggering the onset of IBD [63]

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Direct evidence for DMT1-mediated Mn transport is lacking, with only indirect evidence from an early study (Erikson and Aschner, 2006)