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The peptides selected for cancer vaccine development can be classified in two main type: tumor-associated antigens (TAAs) and tumor-specific antigens (TSAs), which are captured, internalized, processed and presented by antigen-presenting cells (APCs) to cell-mediated immunity

Because of the glycolytic conversion of glucose to lactate in tumor cells, the tumor microenvironment has been demonstrated to be somewhat acidic (pH 6.07.0), lowering the pH value from that of normal tissues (pH 7.4) and has been exploited to develop pH-sensitive drug liposomes

These interactions play a pivotal role in modulating the activation state of cells comprising the BBB, as well as Ms and microglia, themselves

Enzyme Assays : Measure the activity of PPP enzymes like glucose-6-phosphate dehydrogenase (G6PD) to understand how the pathway is regulated and responds to different stimuli