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Metformin use associated with reduced risk of dementia in patients with diabetes: a systematic review and meta-analysis

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To mitigate the adverse effects of HHcy to wound healing, the supplementation of cofactors (B vitamins, folic acid) or other agents (IL-10) seems to be perspective in the treatment of several diseases, especially in type 2 diabetic patients, patients with various types of ulcers, fractures, or inflammatory bowel diseases

According to several neuropathological reports, it has to be noted that clinical PD can also manifest without any Lewy pathology