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When adverse effects occurred, they were typically mild and transient, with the most common being mild to moderate headaches (similar frequency to placebo groups), minor injection site reactions (redness, slight swelling), and gastrointestinal effects at higher oral doses (nausea, diarrhea)

The function cant be inhibited by pyrilamine and cimetidine, but is inhibited by indomethacin, a cyclooxygenase inhibitor, AH-23848B, an antagonist of the EP 4 receptor subtype, and PDTC, an inhibitor of NF-B

Mitochondria, as the primary metabolic organelle, are strongly implicated in aging and age-related diseases

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