glutathione kidney transplant Untargeted metabolomics of perfusate and their association with hypothermic machine perfusion and allograft failure The Role of Glutathione Metabolism

10.1080/10408398.2021.1916876 [DOI] [PubMed] [Google Scholar] Saghatelyan T., Tananyan A., Janoyan N., Tadevosyan A., Petrosyan H., Hovhannisyan A., et al

IMAC generally relies on the interaction between immobilized metal ions and amino acids on the target analyte that can act as electron-donating groups, such as cysteine, histidine, or tryptophan residues [129131]

In the same study, LC-MS/MS (liquid chromatography coupled with tandem mass spectrometry) was used to quantify the PPP intermediates (i.e., 6PGL, R5P, and S7P) produced by the wild-type and the deletion strains exposed to H 2 O 2

Both events would lead to elevated levels of active Nrf2 and Nrf2 nuclear accumulation