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Hypoxia induces HIF1-dependent epigenetic vulnerability in triple negative breast cancer to confer immune effector dysfunction and resistance to anti-PD-1 immunotherapy
Repeated injections in the same location can cause localized inflammation, lipohypertrophy (thickened fat deposits), or increased nerve sensitivity that amplifies the burning sensation
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Clarifies TCM mechanisms: repairing mucosal barrier, regulating bile acid/microbiota, enhancing intestinal immunity
