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IGF-1/-2-neutralizing monoclonal antibodies inhibit various IGF signaling pathways at the same time but have a lower risk of hyperglycemia than IGF-1R/INSR tyrosine kinase inhibitors, as they do not affect insulin receptor-, which regulates glucose homeostasis [116]

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Concurrently, iron deficiency impinges on lipid metabolism, which attenuates the rate-limiting enzyme in fatty acid oxidationCarnitine palmitoyl transferase 1 (CPT-1)in fetal liver [88]

Iron-dependent cytochrome c 1 expression is mediated by the status of heme in Bradyrhizobium japonicum