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Since COPD is a complex and multifaceted disease, the concepts of phenotypes (i.e., subgroups with prognostic impact) and endotypes (i.e., conditions defined by specific pathophysiological and molecular mechanisms) have begun to be applied to achieve the goal of personalized medicine and a more efficient diagnostic and therapeutic approach

Although the available evidence suggests that ketone bodies are not a factor in the effect of the ketogenic diet on inhibitory synaptic function, ketone bodies have been found to increase brain synaptosomal GABA content [51], as occurs with the anticonvulsant vigabatrin [52], raising the possibility that ketone bodies might have functional effects similar to those of vigabatrin

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