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The S-conjugates inside the bile duct can be absorbed by the gut to blood circulation and proceed for renal secretion either being metabolized inside the gut lumen [184] or excreted to feces (as found for the sulfuric acid ester of the carcinogen 1-methylpyrene [185])
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Conversely, excessive supplementation with exogenous antioxidants can weaken these positive ROS-mediated signals
