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Substantially, selection and design of ligands may be performed by using a template which is a part of a natural protein-ligand couple, modelling a molecule which complements the binding sites of the target or directly resembling the natural interactions [2]

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doi: 10.1073/pnas.88.16.7247

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J Cell Biochem 59:2432

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(PubMed) Gritz DC, Srinivasan M, Smith SD, et al

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