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Abbreviations ARE: Antioxidant response element CAT: Catalase Cys: Cysteine FFAR: Free fatty acid receptor GSH: Glutathione reduced GPR: G protein-coupled receptor GST: Glutathione-S-transferases Glu: Glutamate HO-1: Heme oxygenase-1 H 2 O 2 : Hydrogen peroxide Keap-1: Kelch-like ECH-associated protein 1 MAPK: Mitogen-activated protein kinase NF-B: Nuclear factor kappa beta Nrf2: Nuclear factor-erythroid 2 related factor 2 ROS: Reactive oxygen species SOD: Superoxide dismutase STAT3: Signal transducer and activator of transcription 3 References Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB, Flint HJ, Salminen S, Calder PC, Sanders ME (2014) Expert consensus document

Transfection of siRNAs and senolytic screen Druggable genome siRNA libraries were purchased from Horizon Discovery (human siGENOME SMARTpool)

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