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In addition, compared to placebo, patients receiving selegiline developed freezing of gait and on-off motor fluctuations less frequently
By pumping the accumulated, unbound cytosolic catecholamines backward across the plasma membrane and safely into the extracellular synaptic space, the neuron is able to maintain its free cytoplasmic neurotransmitter levels below toxic thresholds , directly protecting itself from oxidative cell death and preserving neuronal viability (Underhill et al., 2021)
A comparative clinical study did find meaningful shedding reduction with two types of peptide-containing topical serums in women with telogen effluvium [3]
Nat Commun 9 , 4293 (2018)
