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Nef promotes neuropathology by upregulating CCL2 in microglia and enhancing IL-6 and IL-8 production in astrocytes [137,138,139], while also activating NADPH oxidase in phagocytes, thereby exacerbating neuroinflammation, myelin damage, and neuronal injury [134, 140]

Although a large number of studies have proposed risk factors for this autoimmune disease, the mechanism of fibrogenesis and the interplays between SGECs and immune cells in SS remain poorly understood

Gastrointestinal Protection BPC-157 has shown protective and healing effects on the GI tract in numerous models, including NSAID-induced ulcers, inflammatory bowel disease models, and alcohol-induced damage

Cost of severe chronic obstructive pulmonary disease exacerbations in a high burden region in North India