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The absolute rate of conductive heat transfer is directly related to the temperature gradient between the objects, the thermal conductivity of the materials, insulation between the objects (e.g., clothing), and the surface area of contact

marciorubin.com.br Nitric-Oxide Signaling: Activates endothelial NO synthase, enhancing micro-circulation and nutrient delivery
So a tiny little needle, and it needs to be near the site of injection, not right on the site of injection, because that where the, I mean, site of injury, not injection