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Untreated vitamin B12 deficiency may result in subacute combined degeneration of spinal cord or irreversible neuropathy, which may occur in the absence of megaloblastic anaemia

Recently, a class of proteins known as SIRTS or sirtuins (also known as silent information regulator 2 [Sir2]-related enzymes) has been implicated in an effect of CR on lifespan extension and the prevention of comorbidities associated with obesity [233, 234]

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