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Ann Rheum Dis 73:15491551 [DOI] [PMC free article] [PubMed] [Google Scholar] Schofield RC, Ramanathan LV, Murata K, Grace M, Fleisher M, Pessin MS, Carlow DC (2015) Development and validation of a turbulent flow chromatography and tandem mass spectrometry method for the quantitation of methotrexate and its metabolites 7-hydroxy methotrexate and DAMPA in serum

The most frequently used tests involve the measurement of plasma concentrations of endogenously produced compounds, such as bilirubin and bile acids, and determination of the rate of clearance of exogenous compounds, such as aminopyrine, lidocaine, and caffeine

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