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In elderly persons, for example, serum total homocysteine concentration is often elevated in those whose folate status is normal but who have a clinical response to B12 treatment (Stabler et al., 1996)

Recently, a class of proteins known as SIRTS or sirtuins (also known as silent information regulator 2 [Sir2]-related enzymes) has been implicated in an effect of CR on lifespan extension and the prevention of comorbidities associated with obesity [233, 234]

Overall, the optimized tripeptide-1 holds great potential as a novel and efficacious ingredient in cosmetics, warranting further exploration in cosmetic formulation and clinical trials

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