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Lynch syndrome (hereditary non-polyposis colorectal cancer) and endometrial carcinoma

doi: 10.1016/j.cell.2012.03.042 28 DixonS

The prolyl isomerase Pin1 acts as a novel molecular switch for TNF-alpha-induced priming of the NADPH oxidase in human neutrophils

The nuclear factor-erythroid 2-related factor 2 (Nrf2) involves multiple aspects of cellular and organismal defense against oxidative stress, such as detoxification, regulating cell metabolism, and promoting cell proliferation, which is crucial in the pathological mechanism of various diseases
