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The animal study protocol was approved by the Institutional Animal Care and Use Committee of Texas A&M University (College Station, TX, USA) following IACUC 2020-0322 (REF#: 166019) per the Animal Welfare Act and Regulations of the United States Department of Agriculture

Much of the mechanistic insight stems from animal models or in vitro systems, which may not accurately replicate the physiological complexity of human perimenopause

10.1186/s13229-016-0099-3 49
