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Pb 2+ disrupts the glutamate-glutamine cycle by suppressing glutaminase (GLS) activity and GLAST/GLT-1 expression, while paradoxically enhancing K + -stimulated glutamate releasea formula for synaptic glutamate spillover (126, 127)

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These processes occur when there is an imbalance between lipid oxidation and the antioxidant system, leading to cell rupture and death and eventually ferroptosis ( Enzymatic Lipid Peroxidation Enzymatic lipid peroxidation is mainly mediated by the lipoxygenase (LOX) family, which is a group of haeme-type iron-containing enzymes that catalyse PUFAs, primarily adrenergic acid (Ada) and arachidonic acid (AA)