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Ultra-small platinum nanoparticle-enabled catalysis and corrosion susceptibility reverse tumor hypoxia for cancer chemoimmunotherapy

Given the high hemoglobin content in RBCs, this mechanism likely operates in parallel, positioning CYB5R3 as a central regulator of both hemoglobin activity and NO signaling dynamics

When ROS levels rise beyond control, oxidative stress increases and begins to disrupt normal cell function

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