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Glutathione levels take time to build
Depletion of total GSH also directly impacts on E GSH and thus mutants with defects in GSH biosynthesis may cause constitutive activation or inactivation of respective signaling pathways
Deng G, Lane C, Kornblau SM , Goodacre A, Snell V, Andreeff M, Deisseroth AB
found that TMPO-AS1 regulates TMPO transcription by forming biomolecular condensates with FUS and p300, leading to the progression of esophageal squamous cell carcinoma 42
