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While waiting for new scientific evidence and more clarification, we can affirm that a daily moderate use of coffee (without sugar) is a reasonable non-pharmacological treatment for these patients, always keeping in mind the great importance of adopting a correct lifestyle, not exceeding fat and alcohol intake, performing constant physical activity, and regular screening

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doi: 10.1212/wnl.51.6.1562

Furthermore, three months of treatment with NitroSynapsin, a compound exhibiting dual memantine-like action and redox-based inhibition of extrasynaptic NMDA receptors, was effective in increasing sociability in Mef2c +/ mice [52]