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The current thought suggests that nitrate supplementation affords the greatest advantage in untrained individuals, but it is an effect that is diminished as the individual becomes more trained ( Future directions Although research on NO and nitrate supplementation has made significant progress during the past 3 decades, there are still many avenues to be explored and gaps to be filled

Furthermore, the supporting cell types that are incorporated into the co-culture models may be from sources or cell lines

NPs, through their potential to simultaneously modulate multiple pathways, emerge as promising candidates for developing innovative antifibrotic therapies

References Zhang, S