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For example, only one study from nearly a decade ago reported a modest but significant neuroprotective effect of KIRA6, an allosteric IRE1 inhibitor, in retinal degeneration models

Treatment continued for two months, followed by a two-month break

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The guide cannula measured 2.5 cm in overall length and was prepared with a heat bulge placed 2.5 mm from its beveled tip, thus acting as a stop to control the depth of penetration
