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Description
The Biochemical Journal
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Modulation of cardiac anaplerosis As described above, anaplerotic flux through pyruvate carboxylation is elevated in compensated hypertrophy, which may affect cardiac lipogenesis and antioxidant defense mechanisms by consuming NADPH
Both animal [76] and human [77] studies suggest that VPA-induced hyperammonaemia may be enhanced via renal rather than hepatic mechanisms
