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doi: 10.1016/j.neuint.2019.104624 69 LiuS.WuQ.XuC.WangL.WangJ.LiuC.et al

If a drug is taken into the gastrointestinal tract (GI tract), where it enters the hepatic portal system through the portal vein, it becomes well-metabolized and is said to show the first pass effect

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In Type 2 diabetes, glutathione supplementation aids in overcoming insulin resistance, reducing excessive insulin secretion-induced inflammation and relieving oxidative stress