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They are defined by impairments in communication and social interaction along with restrictive and repetitive behaviors ( Autism spectrum disorder has been recently estimated to affect 1 out of 68 individuals in the United States ( A great majority of ASD research has concentrated on genetic causes of ASD ( de novo mutations, thereby pointing to acquired mutations and/or mutations secondary to errors in DNA maintenance rather than inherited genetic syndromes ( Recent studies have suggested that ASD is associated with impairments in basic physiological processes such as redox ( Identifying the metabolic or physiological abnormalities associated with ASD is important, as treatments for such abnormalities may be possible

In turn, this prevents polyubiquitination and proteasomal degradation of Nrf2 protein stabilizing its levels (Yamamoto et al., 2018)

doi: 10.1371/journal.pone.0296733