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This compound, which was termed Ferroptosis-Inducer-56 (FIN56), induces the degradation of GPX4 and also acts through the mevalonate pathway to drive increased sensitivity to ferroptosis by depleting CoQ 10

Larger chains may struggle to cross epithelial membranes because their physicochemical properties do not favor passive diffusion, and most are not transported efficiently through active transport pathways

Cargo sorting zones in the trans-Golgi network visualized by super-resolution confocal live imaging microscopy in plants

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