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There is also evidence that propofol acts on the HIF-1 pathway, a crucial component in the regulation of the growth and proliferation of metastatic tumors

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Immunometabolism orchestrates training of innate immunity in atherosclerosis

Furthermore, in vitro studies demonstrated that melatonin can enhance the effect of 5-fluorouracil in colon cancer cells via the activation of caspase-9 and caspase-3 in the mitochondrial apoptotic pathway [160], increasing oxidative stress, downregulating genes and proteins related to apoptosis resistance [161], and inhibiting NF-B/iNOS and PI3K/AKT signaling pathways [162]