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Since the mVCN of the cell product that was infused into these two patients was 1.9 and 2.1, the relatively low mVCN determined 24 months later in the peripheral blood of these two patients indicate that the modified cells may have failed to properly engraft, survive and/or produce -globin (and in consequence hemoglobin), and were therefore unable to meaningfully contribute to hematopoiesis and support correction of the disease