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Consequences of this include oxidative damage to DNA, proteins and cell membrane lipids, and altered cellular signal transductions as observed in many disorders such as diabetes, cardiovascular, autoimmune and chronic kidney diseases [5]

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The -KG carrier (encoded by SLC25A11 ) and the dicarboxylate transport mechanisms (dicarboxylate carrier, encoded by SLC25A10 ) are two potential candidates for importing cytosolic GSH to the mitochondria, mainly in the kidney and liver

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While levodopa (LDOPA) remains the gold standard for symptomatic treatment, its longterm administration is associated with complications such as motor fluctuations, dyskinesia, and oxidative stress

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