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In addition, the absence of resistance of peptides to breakdown by gastrointestinal proteolytic enzymes (e.g., carboxypeptidases or aminopeptidases) should be mentioned [8], which in practice precludes administrating such a drug to the patient orally and calls for intravenous administration

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Psychological distress, such as low self-esteem, anxiety, and depression, stemming from the altered appearance of the skin (NIAMS, 2023)
