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In addition, the inner-mitochondrial-membrane enzyme dihydroorotate dehydrogenase (DHODH) transfers electrons derived from pyrimidine synthesis to ubiquinone, reducing it to ubiquinol and thereby suppressing ferroptosis in parallel with mitochondrial GPX4 (Mao et al., 2021)

According to the results of these studies, H 2 S treatment has beneficial effects on biochemical and histopathological damage in testicular torsion

For instance, recent studies show that the epigenetic and post-translational mechanisms tightly regulate ferroptosis in other tissues, while their specific roles in ocular cells remain largely unexplored, leaving a critical knowledge gap and hindering the identification of novel regulatory targets (152, 153)

Molecular mechanisms and clinical applications of angiogenesis