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Cardiac sympathetic denervation, detectable via 123 I-MIBG scintigraphy, is strongly associated with disease progression ( Management complications: Cardiovascular symptoms complicate pharmacotherapy by interacting with anti-parkinsonian drugs that modulate autonomic tone, requiring dose balancing and often necessitating cardiology consultation ( 4.3 HIV co-infection and antiretroviral therapy HIV-positive individuals are at increased risk of parkinsonism due to basal ganglia vulnerability to viral neurotoxicity, chronic inflammation, and mitochondrial stress (Denaro et al., 2022

PD was induced using MPTP (30 mg/kg, 60387ES03, Yeasen Biotechnology, China), administered intraperitoneally once daily for five days

Mar Drugs 2021

Specifically, studies have shown that 20 (S)-Rg3 blocks the late stage of autophagy (lysosomal fusion and autophagic lysosomal degradation) in cervical cancer cells, preventing them from maintaining a stable state through autophagy and inducing apoptosis in cervical cancer (HeLa) cells [643]