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for example, SCC from glabrous (smooth, hairless) sun-exposed skin has a lower metastatic rate than SCC arising from the vermillion border of the lip or from scars.[3] Additionally, in the epidermal compartment, melanocytes distribute singly along the basement membrane and can undergo malignant transformation into melanoma
Jaeger KE, Ransac S, Dijkstra BW, Colson C, van Heuvel M, Misset O

The arterial microenvironment: the where and why of atherosclerosis

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