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glutathione s tansferase Frontiers Glutathione transferases: substrates, inihibitors and
Description
Within the nucleus, Nrf2 heterodimerizes with small Maf proteins and binds to cis-regulatory DNA sequences termed Antioxidant Response Elements (AREs)

The iron chelators deferoxamine mesylate and VITE could change these circumstances by increasing GPX4 expression and decreasing iron overload [90]

R.SpagnolV.et al (2020)

Main limitation: selectivity figures (such as an in-vitro ~11.7-fold preference for senescent cells) come from cell models, not humans
