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Here are some groups at higher risk of deficiency: People with gastrointestinal issues: Conditions like pernicious anaemia, Crohns disease, or those who have undergone gastric bypass surgery can affect B12 absorption

In neuronal cells, following the knockdown of PINK1 and Parkin, PINK1 is observed to promote PARIS ubiquitination and Parkin proteasomal degradation through phosphorylation of Parkin and PARIS

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Cytokines are also responsible for occludin redistribution from the tight junction to caveolin-containing vesicles 69 , and MLCK is also involved in the regulation of tight junction proteins through the alteration of ZO-1 protein dynamics 70