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Therefore, reducing the expression of ACSL 4 and LPCAT 3 can decrease the accumulation of intracellular lipid peroxides and inhibit ferroptosis ( Autophagy is a fundamental cellular homeostatic program, and excessive autophagy may trigger cell death, also known as autophagy-dependent cell death ( 4 ) ( 4 expression ( 4 mediates the degradation of ferritin after combining with ferritin heavy chain 1 (FTH 1 ) as a selective autophagic receptor and converts ferritin-bound iron into free iron, thereby inducing ferroptosis ( Figure 1 )

For example, an early microarray study indicated that ATF6 knockdown in MEFs had little impact on the expression of tunicamycin-inducible genes 422

The subclinical deficiency rates of vitamin B 12 are high in developing countries and vegetarian populations because the main source of this vitamin are animal foods