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As compared to healthy controls, subjects with current or remitted MDD presented similarly lower mean C2 levels (Cohens d = 0.2, p 1e-4)

A follow-up phase 2 study reported minimal adverse effects associated with this therapy (Stein et al., 2019), and there are several clinical trials further investigating this protein (NCT05234775, NCT04797247, NCT05004675, NCT03545438, NCT04034485, NCT04790513, NCT04806893, NCT04797104, NCT04798430, NCT03549260)

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(Heme iron, found in meat, fish, and poultry, appears to be absorbed intact.) Ascorbic acid, by maintaining iron in the ferrous state, can enhance the absorption of oral iron, however, the magnitude of this increase is in the range of 10% and only occurs with doses of ascorbic acid, vitamin C of 500 mg or greater