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In a trial of patients with T2DM and a BMI of 27 kg/m2 or greater being treated with semaglutide injection for weight loss, clinically significant hypoglycemia (plasma glucose less than 54 mg/dL) was reported in 6.2% of semaglutide-treated patients versus 2.5% of placebo-treated patients

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Explanation of results The living human spine is habitually loaded by gravity and/or by tension in muscles and ligaments 44,31 , so the natural tendency for intervertebral disc GAGs to swell up in tissue fluid 30 is largely restrained

The column temperature program started with 40 C and was ramped to 150 C at a rate of 7 C/min and then to 230 C at a rate of 9 C/min, and finally held at 230 C for 9 min